TIGP -- Implications of the Darwinian cancer genomics in the personalized brain cancer therapy
- 講者陳彥瑜 教授 (林口長庚紀念醫院)
邀請人：TIGP Bioinformatics Program - 時間2013-03-04 (Mon.) 14:00 ~ 15:10
- 地點資訊所新館106演講廳
摘要
Cancer has been proven a genetic disease that undergoes a rapid Darwinian evolutionary process. Late-stage cancer cells accumulate
hundreds or thousands or more mutations: most of them are passengers while only a handful or more mutations are disease driver. The genetic landscape of cancer is extremely diverse even that they share the same histopathology. Studies confirmed that cancer originating from different tissues may share the same driver mutations and can be effectively treated with the same drugs. These findings suggest a new way to classify cancer by its genetic makeup and that comprehensive catalogue of driver mutations for personalized cancer therapy. We conducted a retrospective genomic analysis by analyzing the entire genome and transcriptome in the tumor cells and the matched control samples from ten glioma patients; each had at least three longitudinal tumor burdens. These 10 patients were classified into three
categories: primary and secondary glioblastomas (grade IV), and other gliomas (grade II and III). Genetic changes suggested that each
recurrent tumor underwent a similar developmental process with a few exceptions that the recurrent tumor was in fact a new incidence. In
additional to point mutations, small INDEL, and copy number changes, the analysis of mobile element insertion provides new insights to the genomic instability and to that the root of tumor formation. Our results deconvolute both the complexity and the evolution of cancer
genome in the original and recurrent malignant brain tumors in human.