中央研究院 資訊科學研究所

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TIGP -- Analysis of Allele-Specific Expression and Isoform Switching Using RNA Sequencing

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TIGP -- Analysis of Allele-Specific Expression and Isoform Switching Using RNA Sequencing

  • 講者黃耀廷 教授 (國立中正大學)
    邀請人:TIGP Bioinformatics Program
  • 時間2013-05-30 (Thu.) 14:00 ~ 15:10
  • 地點資訊所新館106演講廳
摘要

In recent years, massively parallel RNA sequencing (RNA-seq) is rapidly becoming an attractive alternative to microarrays for disease association studies. RNA-seq has been widely used for identifying differential expression genes and splicing isoforms between treatment and control groups. However, existing methods often have little or no power for identifying risk genes with aberrant profiles of allele-specific expression (ASE) and isoform switching in time-series studies. In this talk, we first present our RNA-seq analysis pipeline for detecting aberrant ASE in association studies, which is useful for recessive disorders within nuclear families. Finally, we present current progress and challenges of mining isoform switching from time-series data.