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͛ي༟ৃ
͛ي༟ৃ ᜷d࠯΋݊ίஐͣሯɪл͜ΝЗ९˙جνj ̋ɪοՊe஝ۆٙܝஈଣԸ౤ʺME˙جٙ๟
ICATdiTRAQᅺൗdટഹආБ૰᜗ᄴؓʿሯ ᆽଟf຅Ңࡁঐ੄༰๟ᆽή੽˖ᘠʕ፫ᗆ͛ي
Principal Investigators: ஢ၲกe҂֛ᛄeҽᅃৌeОܔ׼e݄ॱ௫e৷׼༺e஢ඓیe؍΀ܗ ᗅྼ᜕iνϤٙྼ᜕ପ͛ɽඎٙሯᗅྡfމə Τ൚dҢࡁટഹఱஈଣவԬΤ൚ගٙᗫڷdԷ
̋஺ሯᗅ༟ࣘٙʱؓdҢࡁމiTRAQމᅺൗ֛ٙ νjஐͣሯʹʝЪٙ͜ᗫڷeਿΪၾशषٙᗫ
௹ɻܝ޼Ӻࡰjҍտۜe؍ဏݲe؍˖㌦eරဏ͡ ඎ˙ج೯࢝ɓࢁІਗʷ༟ࣘʱؓӻ୕fϤӻ୕ ڷഃdԨ౤ԶΥЪྼ᜕܃הცٙ˖ᘠઞਖ޴ᗫ
ΤމMulti-Qdঐ੄ஈଣʔΝሯᗅᄃהପ͛ٙ༟ ʈՈf޴ᗫሞ˖೯ڌίBMC Bioinformatics 2006
͉޼Ӻ໊޼Ӻ˙ΣɽߧʱމɓਿΪ ࣺٙᜊମdމݴБषኪɪ޴຅ࠠࠅٙᙄᕚfᒱ ࣘfவࢁழ᜗ͦۃ͍ίձʷኪהΥЪdኽ၈݊ ಂ̊
᜗iɚஐͣ᜗iɧഐ࿴͛ي༟ৃi ್˰ޢሊ͛ଡ଼ᔌWHOӊϋேึ౤̈ݴชޥ
ͦۃ˰ޢɪ௰΋ආٙ˙جfϤ̮dҢࡁ͍ί೯ ਿΪ᜗˖΁Ꮸ॰
̬͛ي˖ᘠઞਖiʞӻ୕͛يኪf͉ ߴٙਞϽषݭࣺdЪމᖹᅀႡிݴชޥߴٙԱ
࢝ɓࢁԴ͜ICAT֛ඎҦஔٙʱؓӻ୕f͊ԸҢ ౽ᅆۨ˾ଣɛྼ᜕܃ਞ̋2005ϋTREC
ה੽ɧϋۃක֐ආБ਷ყ޼Ӻ͛৫TIGP͛ي༟ ኽf್Ͼdݴชषݭٙ߉ᜊ஺ଟڢ੬ҞdΪϤ
ࡁਗ਼೯࢝ʔΝ֛ٙඎழ᜗dᏐ͜׵ɽඎٙஐͣ ᑘБٙGenomic Information Retrieval Contestd
ৃኪ೻௹ɻफם͛dͦۃʊϞ15Τኪ͛f͟׵ ਞϽषݭࣺהႡிٙޥߴdஷ੬ί೵ࣛගکึ
ሯ᜗ኪʘ޼ӺiԨ೯࢝ൖᙂʷʈՈdᜫԴ͜٫ ίਞᒄٙ32ඟʕᐏ੻ୋ6ΤfਿΪ᜗˖΁Ꮸ॰
ኪ೻ٝΤܓနန͂කdʦϋኪ೻͡ሗɛᅰε׵ ̰ࣖf͟׵̨ᝄٙݴชषݭၾᆄߕ੬Ϟ޴຅ɽ һ˙ک༆ᛘՉྼ᜕ᅰኽאഐ؈f
˸ֻɧϋʘᐼձf ٙࢨମd̋ɪͦۃהϞٙݴชޥߴே݊͟਷̮ ˢᒄٙᕚͦ૿ΥəІ್ႧԊᏨ॰ᕚʿڌࣸόݟ
༔d͟׵ਿΪ᜗˖΁ݟ༔ʕଘऒՑ஢εஐͣሯ
ආɹdຬɓί೯͛ΌଢɽݴБࣛd̙ঐೌج౤ ɧഐ࿴͛ي༟ৃ Research Groups
ɓਿΪ᜗ Զԑ੄ٙޥߴʿᖹيԶ਷ɛԴ͜fΪϤሊ͛໇ ஐͣሯഐ࿴ཫ಻ ʿਿΪഃᅰඎɽeೌնΤ஝ܛ׌ٙ͛يᔼኪΤ
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͟׵ɽඎٙDNAᛘҏʊ஗ᄿعᏐ͜dίϞ ϋၾ͛ᔼהΥЪਞ̋श၍҅ٙݴชޥߴ޼೯ࠇ ੬ึ΋ཫ಻Չ༰މ୑ଫٙɚॴഐ࿴d್ܝᔟ ᅆۨ˾ଣɛྼ᜕܃ଢ଼ጐεϋ༟ৃᓘ՟e༟ৃᏨ
ࠢٙ༟๕ࠢՓʘɨdESTҏΐʱؓʊϓމ޼Ӻ̌ ೥މಂɧϋfҢࡁཫࠇᔟ͟ʱؓ͟ᑗґ՟੻ٙ ͟ɚॴഐ࿴ٙ˪ݬdପ̙͛ঐٙɧॴഐ࿴ᅼ ॰eІ್ႧԊஈଣe͛ي༟ৃʿਪഈӻ୕ක೯
ঐਿΪ᜗ٙቇΥ˙جʘɓfɰΪމνϤdͦۃ षݭࣺd੽ࣨ㹷აҏΐɪٙ߉ᜊᒈැdܔͭޥ ଡ଼(template)fҢࡁ೯࢝˸ٝᗆࢫމਿᓾٙ૿ ຾᜕dίʦϋୋɓϣਞᒄуᐏ੻24.53%͍ᆽଟ
ʥϞ஢εٙESTʱؓࠇ೥͍ίආБf࿁ɓࡈEST ߴषݭࣺձอጳषݭࣺٙʱɿစʷᜊମᅼόd ձۨɚॴഐ࿴ཫ಻˙جd೯࢝̈ HYPROSP ၾ ௰Գϓᐶމ28%dၾߕ̋Շή௟φٙYork
ʱؓࠇ೥ϾԊd௰ࠠࠅٙӉ᜷ఱ݊Չ͛ي༟ৃ ආϾཫ಻ݴชޥߴਞϽषݭࣺ݊щʊ຾Ⴣᕎͦ HYPROSP II Շࡈɚॴഐ࿴ཫ಻ٙ೻όdਗ਼๟ UniversityeIBMeUniversity of WaterlooeUIUC
ʱؓdϾԄλٙҏΐൗ༆ӻ୕ঐ০࿁፩ɝٙEST ۃݴБٙषݭࣺૄ໊dપ಻̙ঐอጳݴБٙष ᆽଟ౤؁Ց82%̸̛fவ˙جഐΥPHIPREDٙ ʿNational Library of MedicineNLMڢ੬ટ
Research Groups
ҏΐ౤Զ௰ҁ዆༟ৃdԨ՘п͛يኪ࢕ආБһ ݭࣺૄ໊d౤ԶԣޥఊЗһอޥߴषݭࣺٙ༟ ዚኜኪ୦ۨཫ಻˙جၾҢࡁה౤̈ٙٝᗆࢫཫ ڐf༈ྼ᜕܃ڌͪϤϣ͟׵ڋϣਞ̋dසਂə
ଉɝٙ޼Ӻfίཀ̘఻ϋʕdҢࡁ΋ܝၾ͛ᔼ ৃf ಻˙جdࣖ؈ˢɚ٫ѩԳf޴ᗫሞ˖೯ڌί ᗫᒟοʿᗫᒟ൚˪Ⴇᓒ࢝d͊Ըਗ਼ึ̋ɝһε
ה఻З͛يኪ࢕ҁϓəՇࢁESTҏΐൗ༆ӻ୕d Nucleic Acids Research 2004˸ʿBioinformatics ͛ᔼჯਹٝᗆٙ༶͜dܵᚃҷආӻ୕d౤ʺᏨ
˸౽ᅆۨ˾ଣɛӻ୕މਿᓾٙ͛ي༟ৃ዆Υ
ΤމBio101ʿBio301iϤ̮Ԩீཀஐͣሯdomain ॰ഐ؈͍ٙᆽଟf
͉ה޼೯ٙၣ༩˾ଣɛҦஔdʊ຾ϓ̌ή 2005ಂ̊f຅ฏεஐͣሯഐ࿴஗ᆽ֛dٝᗆࢫ
፫Ⴉٙ˙ج޼೯əҞ஺ٙESTൗ༆೻όf
Ꮠ͜ί΢၇ਠุჯਹfίኪஔ޼ӺٙᏐ͜ɪd ᎇʘϓڗd๟ᆽଟ޴ڦ͵ึᎇʘ౤ʺfϤ̮d ʞӻ୕͛يኪ
˸঑ಖਗيމͦᅺʘΝ๕࿁݈ൗ༆ӻ୕ ۆഹࠠ׵͛ي༟ৃٙ༟ৃ዆ΥਪᕚdԨ˲ʊ຾ ҢࡁԨഐΥ͛يٝᗆၾዚኜኪ୦Ҧ̷ආБ஢ ˸ӻ୕͛يኪމഄଫԸ༆ؓɛᗳϓᐖཀ೻ၾष
ਈ಻ʔΝي၇ਿΪଡ଼ගٙΝ๕ਜਹ݊ˢ ᐏ੻஢εᘒ൮ٙᏐ͜຾᜕fவԬϓ؈ʊ຾೯ڌ ε޴ᗫٙഐ࿴ཫ಻޼Ӻdᙅνjlocal structure, ࡡߧषዚᔷʘஐͣሯʹʝၣ༩
༰ਿΪ᜗ኪʕɤʱᗫᒟٙӉ᜷fהϞ঑ಖᅼό ί2ᇐሞ˖fމੂБ਷߅ึਿΪᔼᖹ਷࢕ۨࠇ b-turn, transmembrane helix predictionഃഃf ͟׵ਿΪ᜗ࠇ೥ٙҞ஺ආ࢝dε၇͛يʘ
ਗيਿΪଡ଼ගٙΝ๕࿁݈Ϟп׵ਿΪစʷٙ҃ ೥ʘ͛ي༟ৃࣨːண݄؂ਕࠇ೥dҢࡁ՘ ˸˪ݬࠠଡ଼جཫ಻ஐͣሯɧၪഐ࿴ ਿΪ᜗ʊ஗༆ᇁ̈ԸdШ݊࿁׵࢝ତ͛նዚঐ
ᝈᝈ࿀dʔΝ׵ఊ੽ਿΪԉܓ̈೯dΝ๕࿁݈ пʕ޼৫͛ᔼה௓۪ਫ਼הڗ˴ܵʘ਷࢕ਿΪۨ Ңࡁࠇ೥ක೯̥л͜ஐͣሯҏΐ༟ࣘཫ ٙஐͣሯ᜗ٙ޼ӺdۆΪྼ᜕Ҧஔၾ޼Ӻҿࣘ
̙౤ԶһϞɢ˲ᄿعٙਿΪଡ଼༆ᇁdԨމˢ༰ ᛠ֛ʕː(National Genotyping Center, NGC)SNP ಻ஐͣሯ˴᜗࿴ிٙ˙جfމə༺ϓϤͦᅺd ٙልᕏܓჃ༰ਿΪ᜗ʱؓމ৷d዆᜗ٙ޼Ӻ໔
ਿΪ᜗ኪ౤Զᖢոٙਿᓾfਿ׵Ңࡁʘۃл͜ Ensemble༟ࣘࡑᎷܔໄࠇ೥dл͉͜ྼ᜕܃ٙ Ңࡁਗ਼л͜ʘۃܔ࿴λٙஐͣሯ˪ݬ༟ࣘࢫʿ Ӊଫฆᇠ࿔fෂ୕ٙஐͣሯʹʝЪ͜޼Ӻdʔ
UniMarker˙جరҬɛཽගΝ๕࿁݈ٙϓ̌຾ ˾ଣɛӻ୕዆Υᆄeߕe˚ତϞʘၣ༩ SNP ༟ һආɓӉήʱؓ༟ࣘࢫʕҏΐ˪ݬၾഐ࿴ٙᗫ ၍݊࿁዆ࡈஐͣሯ᜗א݊఻ࡈत֛ਿΪପيd
᜕dҢࡁࠇ೥০࿁঑ಖਗيක೯Ν๕࿁݈ൗ༆ ࣘࢫʿҏΐʱؓӻ୕fϓ̌ήܔͭəFastSNPၣ ڷfί΋ۃٙഐ؈ʕdҢࡁ࢝ͪəϤɓܔ࿴λ ࠅᐝ༆வԬஐͣሯʘගٙʹʝၣ༩d̀඲ࠅආ
ӻ୕f ༩؂ਕӻ୕dঐл͜ၣ༩˾ଣɛdІਗЕટ11 ٙஐͣሯ˪ݬ༟ࣘࢫ̙މஐͣሯഐ࿴ࠠܔʿཫ Бɽ஝ᅼٙྼ᜕dঃ൬ɽඎٙࣛගeږ፺ၾɛ
ɽˉܓ̶ඎҏΐʱؓʿՉίʱɿစʷ༟ৃኪʘ ࢭᆄeߕe˚ʘၣ༩ SNP ༟ࣘࢫʿҏΐʱؓʈ ಻౤ԶəԄλٙਿᓾf੽ڗჃԸ޶dஐͣሯҏ ɢdʑঐɓጕΌႶfϞᛠ׵Ϥdމə̂ʱл͜
Ꮠ͜ ՈdᜫਿΪ᜗ᛠ֛ʕːٙ޼Ӻ٫dঐҞ஺ήጜ ΐʿՉഐ࿴ʘගٙᗫڷ݊ࠇၑ͛يኪʕɤʱϞ Ϟࠢٙ༟๕d͉ࠇ೥Ҏૐீཀˢ༰ஐͣሯ᜗ኪ
ίܝਿΪଡ଼ٙࣛ˾ʕd̙˸͜Ըࠠܔစ ፯ࠠࠅٙSNPԸආБਿΪۨᛠ֛(Genotyping)f ܿ኷׌ٙਪᕚdΪϤҢࡁႩމϤਪᕚ޴຅ࠠࠅ (Comparative Proteomics)ٙ˙جdਗ਼ତϞʊٝٙ
ʷᗫڷٙਿΪʿي၇စʷዝ̦ٙҏΐdᅰඎʊ ϓ؈ίජ׼ɽኪᑘ፬ʘBioinformatics in Taiwan Ԩ˲࠽੻ҳءɛɢ޼Ӻf ஐͣሯʹʝЪ͜ᗫڷdᔷʷމҏΐᅼଡ଼ၾᅼଡ଼
຾ᄣ̋Ցڢ੬ᜓɛٙήӉfෂ୕ٙࠇၑʈՈே (BIT-2003)޼ীึʕ೯ڌdί̍ў4З਷̮ኪ ʘගٙᗫڷdᔟϤܔͭ୕ࠇᅼۨdԸཫ಻̙ঐ
੽ࣨှ΍ࣈ/.3༟ࣘཫ಻˴ᗡ
̥ঐஈଣˇඎٙҏΐ༟ৃdतй྅݊˸௰Գʷ ٫הଡ଼ϓٙ൙፯։ࡰึʕ஗൙፯މPoster Paper πίٙஐͣሯʹʝၣ༩ݖ࿴dԨ̙˸ீཀவᅵ
ࣨှ΍ࣈ݊Ӕ֛ஐͣሯഐ࿴੬ٙ͜ྼ᜕Ҧ
οʩ˙όܔͭစʷዓᗫڷٙ˙جdცࠅ޴຅ɽ AwardୋɓΤf͉ϓ؈Νࣛਗ਼೯ڌί2006ϋಂ̊ ஔfࠅ੽NMRྼ᜕ᅰኽӔ֛ഐ࿴ࣛdཫ಻˴ᗡ ٙዚՓԸൗ༆ԟԬ͊ٝ̌ঐٙஐͣሯd˸ʿҬ
ඎٙࠇၑi຅ҏΐᅰͦᄣ̋ࣛdఱ఻˷ೌجί Nucleid Acid Research ٙWeb Server ਖ਼̊ʕfਿ ̈ҲစᗫᒟԉЍٙஐͣሯfவᅵٙၣ༩ݖ࿴d
݊ՉʕɓධࠠࠅٙʈЪiவධʈЪ˸ֻ͟ɛʈ
Ϟࠢٙࠇၑ༟๕ɨࠇၑҁϓfίவࡈࠇ೥ʕd Ϊ᜗ᛠ֛ʕːٙ޼Ӻ٫л͉͜ӻ୕ʊ຾ίᖹي ஈଣd݅ᐿိɦঃࣛfҢࡁʊ຾೯࢝ɓࢁృᐑ Ύ̋ɪၾ˾ᑽ௄ࢰeਿΪʱᗳၾࣛ٤ߠ౻ഃ޴
Ңࡁ޼Ӻձஈଣ̶ඎҏΐર዆ԨઞীνОܔͭ ཀઽ޴ᗫٙਿΪۨ޼Ӻɪᐏ੻ࠠɽϓ؈f နආόٙစၑجfவࡈစၑج஗RECOMB2005 ᗫٙൗ༆dک̙˸՘пҢࡁᐝ༆ίʔΝٙ೯ԃ
˼ࡁٙစʷᗫڷfҢࡁ஝ྌܔͭɓࡈ༆Ӕਪᕚ (FOF 0OUPMPHZ዁Ъழ᜗޼೯ ટաfRECOMB݊ࠇၑ͛يኪޢ௰ࠠࠅٙึ චݬeᐖ୚ߤ͛ϓᔷ୅ʿषࡡชݑʘყd̙ঐ
ٙᐑྤd೯࢝ϞࣖଟٙစၑجԸܔͭɽˉܓʘ ٙପ͛ஐͣሯၣ༩dආϾ੽ʕҬՑҵՓᐖ୚ߤ
͟׵Gene Ontolog(GO)ਂމਿΪ̌ঐൗ༆Ϟ ᙄdҢࡁவᇐሞ˖݊RECOMBᑘ፬ɘϋ˸Ըୋ
စʷዓd˸ʿ̙˸͜Ըᝈ࿀൴ॴዓٙൖᙂʷʈ ஼နᄣ̋ٙᒈැdତίϞ൳Ը൳εٙ͛ي༟ৃ ɓϣϞ̨ᝄٙሞ˖஗ટաf2005ϋԭݲɰසϞ ͛ϓၾᔷ୅ٙᗫᒟΪɿd˸ʿԣ˟षࡡชݑၾ
Ոd̤̮ɰක೯̍ўʔΝࠇၑʈՈٙ༆ᕚᐑྤ ӻ୕ପ͛ٙ༟ࣘேၾGOϞᗫfމəᜫ͛يኪ࢕ Շᇐ஗ટաf͊ԸίஈଣNMRᅰኽӔ֛ഐ࿴ ልႡٙዚᔷfͦۃ͍л͜ןዎଣሞ(Topology)
ձՈɛ׌ʷٙԴ͜٫ʧࠦfҢࡁʊ຾೯࢝̈ɓ ঐһ˙کή዁Ъ༟ࣘdҢࡁணࠇəɓࡈழ᜗၈ ࣛdɰࠅϽᅇл͜NOEྼ᜕ٙᅰኽ੻Ց఻ОЗ ၾྡኪ(Graph Theory)ഃၣ༩͛يኪNetwork
ࢁൖᙂʷӻ୕d౤Զɽˉܓҏΐર዆ʘˢ༰ʈ މGOBUfϤழ᜗ʪ஢ண֛΂จۨ࿒༟ࣘd༟ࣘ ໄɪٙ༟ࣘfҢࡁਗ਼೯࢝စၑجԸʱؓNOEྼ Biologyٙ฿ׂdԸආБӻ୕͛يኪʱؓdਗ਼
Ոd၈މSinicViewfவࡈʈՈ̙˸ᜫԴ͜٫ ̙ၾྼ᜕܃޼ӺɛࡰɓΝԸආБʹʝЪٙ͜ྼ
዆ΥdԨ̙ᓒ̂Դ͜٫ʧࠦdΪϤቇΥ͜ί΢ ᜕ᅰኽdԨ͜Ϥʱؓഐ؈Ըҷഛ˴ᗡཫ಻ٙഐ
Դ͜Іʉٙҏΐ༟ࣘdˢ༰ʔΝҏΐર዆೻ ၇ʔΝٙ͛ي༟ৃᏐ͜ʕfͦۃҢࡁʊਗ਼Ϥழ ؈fϤ޼Ӻ݊ၾ͉৫͛يᔼኪה΍ΝΥЪf ᜕᜕ᗇdԨཫ΋༆ؓ዆ࡈஐͣሯʹʝЪ͜ၣ༩
όהପ͛ٙഐ؈ʘගٙࢨମdԨ፯኿௰ቇΥ ᜗Ꮠ͜ՑҢࡁٙESTҏΐൗ༆ӻ୕ʿɓԬฆ৬ΐ ٙ዆᜗฿رdጜ፯̈ᗫᒟٙஐͣሯdආϾ՘п
ٙഐ؈ආБܝᚃٙʱؓʈЪfϓ؈ʊ຾೯ڌί ྼ᜕ʱؓf ̬͛ي˖ᘠઞਖ อۨᖹيٙක೯ၾطᐕҦஔٙ߉ॎf
BMC Bioinformatics 2006ಂ̊fආɓӉ༟ৃ̙ ͛يਖ਼ϞΤ൚˸ʿ൚ගᗫڷפ՟
ІਿΪ᜗޼ӺʕːࠇၑਿΪ᜗ྼ᜕܃ၣࠫhttp:// ɚஐͣ᜗ ౽ᅆۨ˾ଣɛྼ᜕܃೯࢝ɓࢁ੽͛ᔼ
biocomp.iis.sinica.edu.tw/ ՟੻f Դ͜ሯᗅᄃ༟ࣘٙஐͣሯ֛ඎʱؓ ˖ᘠʕІਗ፫ᗆ͛يΤ൚ٙӻ୕fϤӻ୕݊મ
ݴชषݭʱؓၾޥߴषݭࣺཫ಻ ͦۃஐͣሯ֛ඎʱؓdഹࠠ׵ஐͣሯίʔ ͜ஈଣІ್ႧԊɪٙ௰ɽ඾ܓME˙جdԨ
ʱؓݴชޥߴਞϽषݭࣺձՉ˼อጳषݭ Νٙ୚ߤً࿒ɨٙ޴࿁ڌତʘˢ༰fՉྼ᜕Ӊ

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