Getting the best out of multiple sequence alignment methods in the genomic era
- LecturerDr. Cedric Notredame (Senior Group Leader in the Bioinformatics and Genomics Programme, at the Centre for Genomic Regulation (Barcelona))
Host: Dr. Wen-Lian Hsu - Time2010-07-23 (Fri.) 10:30 – 12:00
- LocationAuditorium 106 at new IIS Building
Abstract
Abstract :
The assembly of multiple sequence alignments is one of the most common
tasks in biology. Interestingly, the methods used for
reconstructing these alignments are merely heuristics, and more or
less well characterized from a biological or a mathematical point
of view. The recent increase in the volume of available data is
stressing these methods to their limits and the time has come to
explore new strategies for coping with the outcome of high-throughput
projects (structure, genomics, mass-spec, etc…). During this talk,
I will review the current challenges and limitations of existing
methods. I will discuss in detail consistency based methods and show
why they could constitute the framework of data integration, at all
possible levels. Among other things, I will discuss the integration
of alternative methods (mcoffee), the integration of sequence and
structure based methods (Expresso) and the alignment of RNA
sequences using secondary structure information. All the methods
presented here are freeware open source that can be either directly
accessed or downloaded from the T-Coffee web server
(www.tcoffee.org).