In the next decade we will begin to face very large sensor-generated datasets on the order of zettabytes or even yottabytes. While centralized control and applications may still be needed, the bulk of computing and storage operations must be distributed near the sensors due to the sheer volume of the data involved. For flexibility in deploying sensors and other resources such as computing and storage nodes, use of networked wireless communications will be essential. We will need new technologies to cope with modest bandwidths in wireless communications while being able to take advantage of their broadcast capabilities. These call for a holistic approach in wireless computing, networking and sensing. This talk will discuss fundamental opportunities and challenges and recent research progress at Harvard and elsewhere in these areas.