Institute of Information Science, Academia Sinica

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Seminar

TIGP--Physico-chemical principles governing biological processes

  • LecturerDr. Carmay Lim (Institute of Biomedical Sciences, Academia Sinica)
    Host: Miss Elsa Pan
  • Time2010-05-27 (Thu.) 14:00 – 15:00
  • LocationAuditorium 101 at new IIS Building
Abstract
Abstract Our research interests are to (i) unravel the underlying physico–chemical principles governing biological processes, (ii) develop new methods, as required, along the way and (iii) use the above principles and methods to design molecules with potential therapeutic utility. This talk will highlight our key accomplishments in these three areas. 1.Metal Binding Affinity and Selectivity in Metalloproteins: Insights from Computational Studies. Todor Dudev & Carmay Lim*, Annual Reviews in Biophysics. (2008) 37:97–116 2.Physical Basis of Structural and Catalytic Zn�{binding Sites in Proteins. Yu-Ming Lee & Carmay Lim*, J. Mol. Biol. (2008) 379:545–553. 3.Common Physical Basis of Macromolecule–Binding Sites in Proteins. Yao Chi Chen & Carmay Lim*, Nucleic Acids Res. (2008) 36:7078-7087. 4.Predicting RNA–binding sites on proteins based on electrostatics, evolution, and geometry. Yao Chi Chen & Carmay Lim*, Nucleic Acids Res. (2008) 36(5): e29.