Institute of Information Science, Academia Sinica

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Seminar

TIGP--Computing tissue-specific co-expression network: practice on Arabidopsis thaliana

  • LecturerDr. Wen-Dar Lin (Institute of Plant and Microbial Biology, Academia Sinica)
    Host: Elsa Pan
  • Time2011-03-17 (Thu.) 14:00 – 15:00
  • LocationAuditorium 106 at new IIS Building
Abstract

In the post-genomic era, public databases like GEO and NASCArrays provide a large volume of array data. These array data of various experimental conditions give scientists a base for computing co-expression gene modules. In order to study iron(Fe)-responsive and phosphate(P)-responsive genes in Arabidopsis roots, we developed the MACCU toolbox (http://maccu.sourceforge.net/) for co-expression computation. In addition to computing co-expression networks based on publicly available array data, we used MACCU to compare co-expression networks made based on different sets of array data. Accordingly, we deduced root-specific co-expression networks with reduced biological complexity, which help biologists narrow down interesting responsive genes.