Abstract. We are currently in the middle of major sea change in science research from an eradominated by large scale simulation to one dominated by data. This change is due to two factors. First, because of the proliferation of on‐line instruments and other devices we have now access to much more digital information than ever before. Second, our tools to analyze, explore and understand these Data are far more powerful now thanks to advances that have come about because of technologies like large scale data centers, advanced search and data mining algorithms and our ubiquitous on‐line access to the Internet. Together these technologies are evolving into a seamless fabric of client‐to‐cloud computing that will keep us constantly connected to our social networks, monitor our health and empower us with knowledge derived from vast oceans of data. This talk will focus on the evolution of the massive data center into the cloud and how we can use the cloud to change the nature of scholarly and scientific research. Speaker Bio. Dennis Gannon the Director of Engagements in the new eXtreme Computing Group of Microsoft Research. Prior to coming to Microsoft, he was a professor of Computer Science at Indiana University and the Science Director for the Indiana Pervasive Technology Labs and, for seven years, Chair of the Department of Computer Science. His research interests include cloud computing, large‐scale cyberinfrastructure, programming systems and tools, distributed computing, computer networks, parallel programming, computational science and problem solving environments. Gannon led the DARPA HPC++ project and he was one of the architects of the Department of Energy SciDAC Common Software Component Architecture (CCA). He was a partner in the NSF Computational Cosmology Grand Challenge project, the NSF Linked Environments for Atmospheric Discovery and the NCSA Alliance. Heserved on the steering committee of the GGF, now the Open Grid Forum and the Executive Steering Committee of the NSF Teragrid. He has served as the program chair or general chair for Numerous conferences and workshops. Gannon has published over 100 refereed articles and co‐edited 3 books. He received his Ph.D. in Computer Science from the University of Illinois Urbana‐Champaign in 1980 after receiving a Ph.D. in Mathematics from the University of California, Davis.